EGFR Antibody (Y869)

ArtNr	ABC-AP7628h
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	EGFR, ERBB, ERBB1, HER1, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
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Primary Accession	P00533
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Bio References	Aifa, S., et al., Exp. Cell Res. 302(1):108-114 (2005). Adams, T.E., et al., Growth Factors 22(2):89-95 (2004). Ichinose, J., et al., Biochem. Biophys. Res. Commun. 324(3):1143-1149 (2004). Kuribayashi, A., et al., Endocrinology 145(11):4976-4984 (2004). Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB10970
Gene ID	1956
Gene Name	EGFR (HGNC:3236)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	All lanes : Anti-EGFR Antibody (Y869) at 1:1000 dilution Lane 1: A431 whole cell lysate Lane 2: MDA-MB-231 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 134 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Western blot analysis of EGFR (arrow) using rabbit polyclonal EGFR Antibody (Cat.#AP7628h).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EGFR gene (Lane 2) (Origene Technologies).
Type image 2	WB
Dilution image 2	1:1000
Other Accession	Q01279
Predicted	M
Isotype	Rabbit Ig
Calculated MW	134277
Antigen Region	847-876
Antigen Source	HUMAN
Target/Specificity	This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 847-876 amino acids from human EGFR.
NCBI Accession	NP_005219.2; NP_958439.1; NP_958440.1; NP_958441.1

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