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RUNX2 Antibody (N-term)

RUNX2 Antibody (N-term)

ArtNr	ABC-AP7735a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	RUNX2, CBFA1, OSF2, AML3, PEBP2A, Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, CBF-alpha-1, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEBP2-alpha A, PEA2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, OSF-2
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Primary Accession	Q13950
Antigen Type	Synthetic Peptide
Application	IHC-P
Bio Background	Runx2 is a member of the RUNX family of transcription factors. It is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in the Runx2 gene have been associated with the bone development disorder cleidocranial dysplasia (CCD).
Bio References	Rich, J.T., Biochem. Biophys. Res. Commun. 372 (1), 230-235 (2008) Ermakov, S., Ann. Hum. Genet. 72 (PT 4), 510-518 (2008) Endo, T., J. Clin. Endocrinol. Metab. 93 (6), 2409-2412 (2008)
Clonality	Polyclonal
Clone/Animal Names	RB10543
Gene ID	860
Gene Name	RUNX2
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with Runx2 Antibody (N-term) (Cat.#AP7735a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 1	IHC-P
Dilution image 1	1:10~50
Isotype	Rabbit Ig
Calculated MW	56648
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This RUNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human RUNX2.
NCBI Accession	NP_001015051.3; NP_001019801.3

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Menge: 400 ul

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