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PDX1 Antibody (N-term)

PDX1 Antibody (N-term)

ArtNr	ABC-AP7740a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PDX-1, PDX1, STF1, GSF, IDX-1, IPF1, STF-1, Insulin promoter factor 1, IPF-1, Islet/duodenum homeobox-1, Somatostatin-transactivating factor 1, Insulin upstream factor 1, IUF-1, Glucose-sensitive factor, Pancreas/duodenum homeobox protein 1
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Primary Accession	P52945
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in the gene encoding PDX1 are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Bio References	Ma, J., Carcinogenesis 29 (7), 1327-1333 (2008) Watada, H., Biochem. Biophys. Res. Commun. 229 (3), 746-751 (1996)
Clonality	Polyclonal
Clone/Animal Names	RB10459
Gene ID	3651
Gene Name	PDX1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of PDX1 (arrow) using rabbit polyclonal PDX1 Antibody (N-term) (RB10459). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PDX1 gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human testis tissue reacted with PDX1 Antibody (N-term) (Cat.#AP7740a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Isotype	Rabbit Ig
Calculated MW	30771
Antigen Region	40-69
Antigen Source	HUMAN
Target/Specificity	This PDX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human PDX1.
NCBI Accession	NP_000200.1

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ABC-AP7740a-datasheet.pdf

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Menge: 400 ul

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