ZAP70 Antibody (Center)

Primary Antibodies; Immunology; Signal Transduction; Anti-Kinome Antibodies; Immunity; T cell activation; T cell receptor signaling

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

RB3100

Purified Rabbit Polyclonal Antibody (Pab)

69872

252-282

WB: 1:1000
IHC-P: 1:50~100