Hersteller |
Abcepta
|
Kategorie |
|
Typ |
Antibody Primary |
Specific against |
other |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB |
Menge |
80 ul |
Host |
Rabbit |
ArtNr |
ABC-AP8879c-ev |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Primary Accession |
P49798 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. |
Bio References |
Heximer, S.P., et.al., Proc. Natl. Acad. Sci. U.S.A. 94 (26), 14389-14393 (1997) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB21256 |
Gene ID |
5999 |
Gene Name |
RGS4 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M |
Legend image 1 |
Western blot analysis of RGS4 Antibody (Center) (Cat. #AP8879c) in MDA-MB231 cell line lysates (35ug/lane). RGS4 (arrow) was detected using the purified Pab. |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
Western blot analysis of RGS4 Antibody (Center) (Cat. #AP8879c) in mouse brain tissue lysates (35ug/lane). RGS4 (arrow) was detected using the purified Pab. |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
Western blot analysis of RGS4 (arrow) using rabbit polyclonal RGS4 Antibody (Center) (Cat. #AP8879c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RGS4 gene. |
Type image 3 |
WB |
Dilution image 3 |
1:1000 |
Other Accession |
P49799; Q0R4E4; Q4R525; Q29RM9 |
Predicted |
B, Pr, Rb, Rat |
Isotype |
Rabbit Ig |
Calculated MW |
23256 |
Antigen Region |
147-174 |
Antigen Source |
HUMAN |
Target/Specificity |
This RGS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-174 amino acids from the Central region of human RGS4. |
NCBI Accession |
NP_001095915.1; NP_001106851.1; NP_001106852.1; NP_005604.1 |
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