TP73 Antibody (Center)

Synthetic Peptide

TP73 is tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors.

Polyclonal

7161

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Confocal immunofluorescent analysis of TP73 Antibody (Center) (Cat. #AP8881c) with 293 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).

1:10~50

WB

TP73 Antibody (Center) (Cat. #AP8881c) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TP73 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

1:50~100

FC

Q9JJP2

69623

HUMAN

NP_001119712.1; NP_001119713.1; NP_001119714.1; NP_001191113.1; NP_001191114.1; NP_001191115.1; NP_001191117.1; NP_001191118.1; NP_001191119.1; NP_001191120.1; NP_001191121.1; NP_005418.1