NAMPT Antibody (Center)

Synthetic Peptide

NAMPT catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

Polyclonal

10135

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of NAMPT Antibody (Center) (Cat. #AP9010c) in A375 cell line lysates (35ug/lane). NAMPT (arrow) was detected using the purified Pab.

1:1000

WB

Formalin-fixed and paraffin-embedded human skeletal muscle reacted with NAMPT Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

1:10~50

M, Pig, Rat

55521

HUMAN

NP_005737.1