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GABRD Antibody (Center)

GABRD Antibody (Center)

ArtNr	ABC-AP9299c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	GABRD, GABA(A) receptor subunit delta, Gamma-aminobutyric acid receptor subunit delta
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Primary Accession	O14764
Antigen Type	Synthetic Peptide
Application	WB, FC, IHC-P
Bio Background	GABRD is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This protein encodes the delta subunit.
Bio References	Gratacos, M., et.al., Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) Maldonado-Aviles, J.G., et.al., Am J Psychiatry 166 (4), 450-459 (2009) Tabakoff, B., et.al., BMC Biol. 7, 70 (2009)
Clonality	Polyclonal
Clone/Animal Names	RB23938
Gene ID	2563
Gene Name	GABRD
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	All lanes : Anti-GABRD Antibody (Center) at 1:2000 dilution Lane 1: MDA-MB-453 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 51 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:2000
Legend image 2	GABRD Antibody (Center) (Cat. #AP9299c) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GABRD Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	GABRD Antibody (Center) (Cat. #AP9299c) flow cytometric analysis of MDA-MB435 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Other Accession	P22933
Isotype	Rabbit IgG
Calculated MW	50708
Antigen Region	331-358
Antigen Source	HUMAN
Target/Specificity	This GABRD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-358 amino acids from the Central region of human GABRD.
NCBI Accession	NP_000806.2

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