DC-SIGN Antibody

ArtNr	ABC-ASC10125
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Cell Biology Cell Movement Cell Adhesion Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, ELISA, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000;100:587-97. Pohlmann S, Baribaud F, Lee B, et al. RW. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001; 75:4664-72. Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85. Soilleux EJ, Barten R, and Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DC-SIGN Antibody: CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1,CD209 antigen,C-type lectin domain family 4 member L,CD209 molecule
Similar products	DC-SIGN, CLEC4L, DC-SIGN1, CD209 antigen, CD209 molecule, DC-SIGN Antibody: CDSIGN, C-type lectin domain family 4 member L
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Manufacturer - Category	Primary Antibodies; Immunology; Microbiology; Signal Transduction; Host cell receptor for virus entry; Viral entry into host cell; Viral genome replication; Host-virus interaction; Immunity; Innate immunity
Manufacturer - Targets	CD209;
Storage Conditions	DC-SIGN antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	DC-SIGN Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Clonality	Polyclonal
Gene Name	CD209
Reactivity	H
Calculated Molecular Weight	45775
Antigen Source	Homo sapiens
Purification	DC-SIGN Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	DC-SIGN antibody can be used for detection of DC-SIGN by Western blot at 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL.
Positive Control	Human Placenta Lysate; Human Small Intestine Tissue Lysate
Buffer	DC-SIGN Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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