KappaB ras2 Antibody

NKIRAS2;

KappaB ras2 Antibody: KappaB ras-1 (?B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with I?B (I?B), an inhibitor of the transcription factor NF-?B. I?B exists in two homologous forms, I?B-alpha and I?B-beta, although I?B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive I?B-alpha-NF-?B complexes can shuttle in and out of the nucleus, I?B-beta-NF-?B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the I?B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of I?B-beta and regulating the rate of degradation of I?B-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.

NKIRAS2

21508

KappaB ras2 Antibody is affinity chromatography purified via peptide column.

KappaB ras2 antibody can be used for detection of KappaB ras1 by Western blot at 1 µg/mL.

KappaB ras2 Antibody is supplied in PBS containing 0.02% sodium azide.