Bif Antibody

ArtNr	ABC-ASC10425
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Cell Biology Cell Status Western Blot ELISA Immunocytochemistry Senescence Primary Antibodies Immunostaining Immunochemistry
Typ	Antibody Primary
Applikationen	WB, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7. Oltvai ZN, Milliman CL, and Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74:609-19. Cuddeback SM, Yamaguchi H, Komatsu K, et al. Molecular cloning and characterization of bif-1. J. Biol. Chem.2001; 276:20559-65. Takahashi Y, Karbowski M, Yamaguchi H, et al. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol. Cell. Biol. 2005; 25:9369-82.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Bif Antibody: Bif-1,CGI-61,PPP1R70,dJ612B15.2,KIAA0491,Endophilin-B1,Bax-interacting factor 1,Bif-1,SH3-domain GRB2-like endophilin B1
Similar products	Bif-1, CGI-61, KIAA0491, dJ612B15.2, Bax-interacting factor 1, Endophilin-B1, Bif Antibody: Bif-1, PPP1R70, SH3-domain GRB2-like endophilin B1
Lieferbar
Manufacturer - Applications	BIF antibody can be used for the detection of BIF by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL.
Manufacturer - Category	Primary Antibodies; Cell Biology; Metabolism; Autophagy; Mitochondrion; Mitochondrion outer membrane
Manufacturer - Targets	SH3GLB1;
Storage Conditions	Bif antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	Bif Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family such as Bax appear to control the activation of these enzymes. Bax activity was found to be regulated by its association with Bax-interacting factor 1 (BIF), a member of the endophilin B family that is associated with intracellular membranes. Following this interaction, Bax undergoes a conformational change and translocates to mitochondrial membranes. The Bax/BIF interaction appears to be enhanced by apoptotic stimuli, suggesting that BIF acts as the trigger to activate Bax, and as suppression of BIF promoted HeLa cell colony formation in soft agar, it may have a role in the suppression of cancer progression. At least two isoforms of BIF are known to exist.
Clonality	Polyclonal
Gene Name	SH3GLB1
Reactivity	H, M
Calculated Molecular Weight	40796
Antigen Source	Homo sapiens
Purification	Bif Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	BIF antibody can be used for the detection of BIF by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL.
Positive Control	HeLa Cell Lysate
Buffer	Bif Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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Lieferung vsl. bis 01.01.2026

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