TBC1D1 Antibody

ArtNr	ABC-ASC10543
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	White RA, Pasztor LM, Richardson PM, et al. The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, Bub2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. Cytogenet. Cell Genet.2000; 89:272-5. Koumanov F and Holman GD. Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways. Biochem. J.2007; 403:e9-11. Roach WG, Chavez JA, Miinea CP, et al. Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. Biochem J.2007; 403:353-8. Stone S, Abkevich V, Russell DL, et al. TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum. Mol. Genet.2006; 15:2709-20.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Manufacturer - Category	Primary Antibodies; Signal Transduction
Manufacturer - Targets	TBC1D1;
Storage Conditions	TBC1D1 antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	TBC1D1 Antibody: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.
Clonality	Polyclonal
Gene Name	TBC1D1
Reactivity	H
Calculated Molecular Weight	133084
Antigen Source	Homo sapiens
Purification	TBC1D1 Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	TBC1D1 antibody can be used for detection of TBC1D1 by Western blot at 1 - 4 µg/mL.
Positive Control	Daudi Cell Lysate
Buffer	TBC1D1 Antibody is supplied in PBS containing 0.02% sodium azide.

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ABC-ASC10543-datasheet.pdf

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Menge: 100 ug

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