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CDC42 Antibody

ArtNr ABC-ASC10874
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Applikationen WB, ELISA
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Chicken
Isotype IgY
Citations Erickson JW and Cerione RA. Multiple roles for Cdc42 in cell regulation. Curr. Opin. Cell Biol.2001; 13:153-7.
Chen W, Lim HH, and Lim L. The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation. J. Biol. Chem.1993; 268:13280-5.
Hart MJ, Eva A, Evans T, et al. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature1991; 354:311-4.
Rohatgi R, Ma L, Miki H, et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell1999; 97:221-31.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Lieferbar
Manufacturer - Applications
CDC42 antibody can be used for detection of CDC42 by Western blot at 0.5 - 1 µg/mL.
Manufacturer - Category
Primary Antibodies; Cancer; Cell Biology; Signal Transduction; Fc gamma R-mediated phagocytosis; T cell activation; T cell receptor signaling; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling
Manufacturer - Targets
CDC42;
Storage Conditions
CDC42 antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background
CDC42 Antibody: CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to S. cerevisiae CDC42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. CDC42 is thought to regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. At least two isoforms of CDC42 are known to exist.
Clonality
Polyclonal
Gene Name
CDC42
Reactivity
H, M, Rat
Calculated Molecular Weight
21259
Antigen Source
Homo sapiens
Purification
CDC42 Antibody is affinity chromatography purified via peptide column.
Antibody Form
Liquid
Application Notes
CDC42 antibody can be used for detection of CDC42 by Western blot at 0.5 - 1 µg/mL.
Positive Control
Human Brain Tissue Lysate
Buffer
CDC42 Antibody is supplied in PBS containing 0.02% sodium azide.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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