NKX2-2 Antibody

ArtNr	ABC-ASC11446
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Neural Development Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Sussel L, Kalamaras J, Hartigan-O’Connor DJ, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 1998; 125:2213-21 Prado CL, Pugh-Bernard AE, Elghazi L, et al. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc. Natl. Acad. Sci. 2004; 101:2924-9. Hill JT, Chao CS, Anderson KR, et al. Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol. Endocrinol. 2010; 381-90. Briscoe J, Sussel L, Serup P, et al. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signaling. Nature 1999; 398:622-7.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Category	Primary Antibodies; Developmental Biology; Neuroscience; Stem Cells
Manufacturer - Targets	NKX2-2; NKX2-2 antibody is predicted to not cross-react with other NK2 homeobox family members.
Storage Conditions	NKX2-2 antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	NKX2-2 Antibody: NKX2-2 (NK2 homeobox 2) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-2 is crucial in the development of pancreatic islet cell differentiation and activates the ghrelin-promoter in these cells. NKX2-2 is expressed at the onset of pancreatic epithelium formation and becomes restricted to mature ?-, ?- and PP cells, and in NKX2-2-null mice embryos, all ?-cells and most a-cells are replaced by ghrelin-positive cells. NKX2-2 is also thought to be involved in ventral neuronal patterning and floor plate development and commissural axon guidance.
Clonality	Polyclonal
Gene Name	NKX2-2
Reactivity	H, M, Rat
Calculated Molecular Weight	30133
Antigen Source	Homo sapiens
Purification	NKX2-2 Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	NKX2-2 antibody can be used for detection of NKX2-2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Rat Kidney Tissue Lysate
Buffer	NKX2-2 Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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