PTPRD Antibody

ArtNr	ABC-ASC11490
Hersteller	Abcepta
Menge	100 ug
Kategorie	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies Western Blot ELISA Primary Antibodies By Organ Brain Cancer Immunostaining
Typ	Antibody Primary
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Krueger NX, Streuli M, and Saito H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 1990; 9:3241-52. Fischer EH, Charbonneau H and Tonks NK. Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science 1991; 253:401-6. Pan MG, Rim C, Lu KP et al. Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene. J. Biol. Chem. 1993; 268:19284-91. Veeriah S, Brennan C, Meng S, et al. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc. Natl. Acad. Sci. USA 2009; 106: 9435-40.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Category	Primary Antibodies; Neuroscience; Signal Transduction
Manufacturer - Targets	PTPRD; PTPRD antibody is human specific. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. PTPRD cleavage products are often observed in vivo
Storage Conditions	PTPRD antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	PTPRD Antibody: PTPRD (Protein tyrosine phosphatase receptor type D) is a member of the protein tyrosine phosphatase (PTP) family that plays diverse roles during development including cell growth, differentiation, mitotic cycle and oncogenic transformation. PTPRD contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The extracellular region of PTPRD is composed of three Ig-like and eight fibronectin type III-like domains (1, 3). PTPRD interacts with PPFIA1-3 and is a tumor suppressor on chromosome 9p that is involved in the development of glioblastoma multiforme (GBMs) and multiple human cancers.
Clonality	Polyclonal
Gene Name	PTPRD
Reactivity	H
Calculated Molecular Weight	214760
Antigen Source	Homo sapiens
Purification	PTPRD Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	PTPRD antibody can be used for detection of PTPRD by Western blot at 1 - 2 µg/mL.
Positive Control	HeLa Cell Lysate
Buffer	PTPRD Antibody is supplied in PBS containing 0.02% sodium azide.

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