PHOX2B Antibody

ArtNr	ABC-ASC11501
Hersteller	Abcepta
Menge	100 ug
Kategorie	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Brain Cancer Nervous System Cancer Immunostaining
Typ	Antibody Primary
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Stanke M, Junghans D, Geissen M, et al. The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons. Development 1999; 126:4087-94 Young HM, Ciampoli D, Hsuan J, et al. Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxalase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut. Dev. Dyn. 1999; 216:137-52. Pattyn A, Morin X, Cremer H, et al. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 1999; 399:366-70. Coppola E, d'Autréaux F, Rijli FM, et al. Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development 2010; 137:4211-20
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Category	Primary Antibodies; Neuroscience
Manufacturer - Targets	PHOX2B; PHOX2B antibody is predicted to not cross-react with other paired homeobox family members.
Storage Conditions	PHOX2B antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	PHOX2B Antibody: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
Clonality	Polyclonal
Gene Name	PHOX2B
Reactivity	H, M, Rat
Calculated Molecular Weight	31621
Antigen Source	Homo sapiens
Purification	PHOX2B Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	PHOX2B antibody can be used for detection of PHOX2B by Western blot at 1 - 2 µg/mL.
Positive Control	293 Cell Lysate
Buffer	PHOX2B Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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