CASK Antibody

ArtNr	ABC-ASC11505
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Neural Signaling Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Dimitratos SD, Woods DF, and Bryant PJ. Camguk, Lin-2, and CASK: novel membrane associated guanylate kinase homologs that also contain CaM kinase domains. Mech. Dev. 1997; 63:127-30. Hsueh YP and Sheng M. Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J. Neurosci. 1999;19:7415-25. Tabuchi K, Biederer T, Butz S, et al. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with CASKIN2, a novel CASK-binding protein. J. Neurosci. 2002; 22:4264-73. Kuo TY, Hong CJ, Chien HL, et al. X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. J. Neurosci. Res. 2010; 88: 2364-73.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Manufacturer - Applications	CASK antibody can be used for detection of CASK by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Manufacturer - Category	Primary Antibodies; Neuroscience; Signal Transduction; Inflammation mediated by chemokine and cytokine signaling
Manufacturer - Targets	CASK; At least six alternatively spliced transcript variants have been observed.
Storage Conditions	CASK antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	CASK Antibody: CASK (Calcium/calmodulin-dependent serine protein kinase), a conserved multi-domain scaffolding protein, belongs to a MAGUK (membrane-associated guanylate kinase homologs) subfamily and is involved in cell junction organization, tumor suppression and signaling. It is characterized by a novel domain structure that consists of a calcium/calmodulin-dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is ubiquitously expressed and significantly greater in brain where it is thought to be involved in signaling at neuronal synapses. CASK interacts with CASKINs and defects in CASK are the cause of mental retardation X-linked CASK-related.
Clonality	Polyclonal
Gene Name	CASK
Reactivity	H, M, Rat
Calculated Molecular Weight	105123
Antigen Source	Homo sapiens
Purification	CASK Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	CASK antibody can be used for detection of CASK by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Mouse Brain Tissue Lysate
Buffer	CASK Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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