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RAB21 Antibody

ArtNr ABC-ASC11507
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Applikationen WB, IF, ELISA
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Citations Opdam FJ, Kamps G, Croes H, et al. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. Eur. J. Cell Biol. 2000; 79:308-16.
Pellinen T and Ivaska J. Integrin traffic. J. Cell Sci. 2006; 119:3723-31.
Mai A, Veltel S, Pellinen T, et al. Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration. J. Cell Biol. 2011; 194:291-306.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Lieferbar
Manufacturer - Applications
RAB21 antibody can be used for detection of RAB21 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Manufacturer - Category
Primary Antibodies; Cancer; Cell Biology; Signal Transduction
Manufacturer - Targets
RAB21; This antibody is predicted to not cross-react with other Ras-related proteins
Storage Conditions
RAB21 antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background
RAB21 Antibody: RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the ?-tail of endocytosed integrin.
Clonality
Polyclonal
Gene Name
RAB21
Reactivity
H, M, Rat
Calculated Molecular Weight
24348
Antigen Source
Homo sapiens
Purification
RAB21 Antibody is affinity chromatography purified via peptide column.
Antibody Form
Liquid
Application Notes
RAB21 antibody can be used for detection of RAB21 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control
Mouse Kidney Tissue Lysate
Buffer
RAB21 Antibody is supplied in PBS containing 0.02% sodium azide.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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