IL-36RN Antibody

ArtNr	ABC-ASC11713
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Neural Lineage Markers Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining Glial Cell Markers
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75. Debets R, Timans JC, Homey B, et al. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 2001; 167:1440-6. Blumberg H, Dinh H, Trueblood ES, et al. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J. Exp. Med. 2007; 204:2603-14. Towne JE, Renshaw BR, Douangpanya J, et al. Interleukin-36 (IL-36) ligands require processing for full agonist agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. J. Biol. Chem. 2011; 286:42594-602.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Manufacturer - Category	Primary Antibodies; Immunology
Manufacturer - Targets	IL36RN; IL-36RN antibody is human specific. At least two isoforms of IL-36RN are known to exist
Storage Conditions	IL-36RN antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2). The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3). Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4).
Clonality	Polyclonal
Gene Name	IL36RN
Reactivity	H, M
Calculated Molecular Weight	16962
Antigen Source	homo sapiens
Purification	IL-36RN antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	IL-36RN antibody can be used for detection of IL-36RN by Western blot at 1 - 2 µg/ml.
Positive Control	3T3 Cell Lysate
Buffer	IL-36RN antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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