TRPV4 Antibody

TRPV4 antibody was raised against an 18 amino acid peptide near the center of human TRPV4.
The immunogen is located within amino acids 380 - 430 of TRPV4.

The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1). TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2, 3). TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3). TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4).

TRPV4

98281

TRPV4 antibody is affinity chromatography purified via peptide column.

TRPV4 antibody can be used for detection of TRPV4 by Western blot at 1 μ g/ml. Antibody can also be used for Immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.

TRPV4 antibody is supplied in PBS containing 0.02% sodium azide.