WAPL Antibody

ArtNr	ABC-ASC11802
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Kwiatkowski BA, Ragoczy T, Ehly J, et al. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. Exp. Cell Res. 2004; 300:223-33. Kueng S, Hegemann B, Peters BH, et al. Wapl controls the dynamic association of cohesion with chromatin. Cell 2006; 127:955-67. Gandhi R, Gillespie PJ, and Hirano T. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr. Biol. 2006; 16:2406-17. Oikawa K, Ohbayashi T, Kiyono T, et al. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res. 2004; 64:3545-9.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Category	Primary Antibodies; Cell Biology
Manufacturer - Targets	WAPAL; WAPL antibody is human, mouse and rat reactive. At least four isoforms of WAPL are known to exist.
Storage Conditions	WAPL antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	WAPL (wings apart-like), also known as WAPAL or FOE, is a 1, 190 amino acid protein that contains one WAPL domain and may play an important role in cell growth (1). It is expressed in an isoform dependent manner in heart, skeletal muscle (isoform 2) and uterine cervix tumor tissue (isoform 1) (1, 2, 4). WAPL is involved in sister-chromatid adhesion and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits (3, 4). WAPL is a new regulator of the development and metastasis of cancerous tissue (4, 5).
Clonality	Polyclonal
Gene Name	WAPL
Reactivity	H, M, Rat
Calculated Molecular Weight	132946
Antigen Source	homo sapiens
Purification	WAPL antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	WAPL antibody can be used for detection of WAPL by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.
Positive Control	A-20 Cell Lysate
Buffer	WAPL antibody is supplied in PBS containing 0.02% sodium azide.

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ABC-ASC11802-datasheet.pdf

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Menge: 100 ug

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