PINK1 Antibody

ArtNr	ABC-ASC11814
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Neuroinflammation Neural Mitochondrial Function Protein Aggregation, Clearance & Misfolding Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Matsuda S, Kitagishi Y, and Kobayashi M. Function and characteristics of PINK1 in mitochondria. Oxid. Med. Cell. Longev. 2013;601587. Corti O, Lesage S, and Brice A. What genetics tells us about the causes and mechanism of Parkinson’s disease. Physiol. Rev. 2011; 91:1161-218. Deas E, Plun-Favreau H, and Gandhi S, et al. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum. Mol. Genet. 2011; 20:867-79. Valente EM, Abou-Sleiman PM, Caputo V, et al. Hereditary early-onset Parkinson’s disease caused by mutations in PINK1. Science 2004; 304:1158-60.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Applications	PINK1 antibody can be used for detection of PINK1 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Manufacturer - Category	Primary Antibodies; Cardiovascular; Metabolism; Neuroscience; Signal Transduction; Autophagy; Mitochondrion; Mitochondrion outer membrane
Manufacturer - Targets	PINK1 antibody was raised against a 16 amino acid peptide near the amino terminus of human PINK1. The immunogen is located within amino acids 120 - 170 of PINK1.
Storage Conditions	PINK1 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1). PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2). PINK1 is cleaved by the mitochondrial protease PARL (3). Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4).
Clonality	Polyclonal
Gene Name	PINK1
Reactivity	H, M, Rat
Calculated Molecular Weight	62769
Antigen Source	homo sapiens
Purification	PINK1 antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	PINK1 antibody can be used for detection of PINK1 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Positive Control	A431 Cell Lysate
Buffer	PINK1 antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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