SMURF1 Antibody

ArtNr	ABC-ASC11844
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot ELISA Senescence Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Huibregtse JM, Scheffner M, Beaudenon S, et al. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 1995; 92:2563-7. Hwang YS, Lee HS, Kamata T, et al. The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1. Genes Dev. 2013; 27:491-503. Yamashita M, Ying SX, Zhang G, et al. Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 2005; 121:101-113. Kwon A, Lee HL, Woo KM, et al. SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion. Mol. Cells 2013; 36:548-55.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Applications	SMURF1 body can be used for detection of SMURF1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL.
Manufacturer - Category	Primary Antibodies; Cell Biology
Manufacturer - Targets	SMURF1; SMURF1 antibody is human, mouse and rat reactive. At least three isoforms of SMURF1 are known to exist this antibody will recognize all three isoforms. SMURF1 is predicted to not cross-react with SMURF2.
Storage Conditions	SMURF1 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1). SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1, 2). SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3). SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4).
Clonality	Polyclonal
Gene Name	SMURF1
Reactivity	H, M, Rat
Calculated Molecular Weight	86114
Antigen Source	homo sapiens
Purification	SMURF1 antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	SMURF1 body can be used for detection of SMURF1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL.
Positive Control	293 Cell Lysate
Buffer	SMURF1 antibody is supplied in PBS containing 0.02% sodium azide.

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ABC-ASC11844-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 01.01.2026

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