RHOT1 Antibody

ArtNr	ABC-ASC11870
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Aging & Neurological Disorders Antibodies Cell Biology Cytoskeleton Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining small GTPases Miro Subfamily
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Fransson A, Ruusala A, and Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J. Biol. Chem. 2003; 278:6495-502. Macaskill AF, Brickley K, Stephenson FA, et al. GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. Mol. Cell. Neurosci. 2009;40:301–12. Weihofen A, Thomas KJ, Ostaszewski B, et al. Pink1 forms a multi-protein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry 2009; 48:2045-54. Wang X, Winter D, Ashrafi G, et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 2011; 147:893-906.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Category	Primary Antibodies; Metabolism; Mitochondrion; Mitochondrion outer membrane
Manufacturer - Targets	RHOT1; RHOT1 antibody is human, mouse and rat reactive. At least three isoforms of RHOT1 are known to exist; this antibody will detect all three isoforms.
Storage Conditions	RHOT1 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	The Ras homolog family member T1 (RHOT) is an atypical Rho Ca2+-binding GTPase that localizes to the mitochondria (1). RHOT1, the related protein RHOT2, the adaptor protein Milton, and the PTEN induced putative kinase 1 (PINK1), form a complex that is involved in axonal transport of mitochondria (2, 3). Both PINK1 and Parkin target RHOT1 for phosphorylation and degradation, causing the arrest of mitochondrial motility (4).
Clonality	Polyclonal
Gene Name	RHOT1
Reactivity	H, M, Rat
Calculated Molecular Weight	70784
Antigen Source	homo sapiens
Purification	RHOT1 antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	RHOT1 antibody can be used for detection of RHOT1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Rat Brain Tissue Lysate
Buffer	RHOT1 antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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