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CDC42BPA Antibody (monoclonal) (M01)

ArtNr ABC-AT1463a
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Monoclonal
Format Liquid
Applikationen WB, ELISA
Clon 1G7
Specific against Human (Homo sapiens)
Host Mouse
Isotype IgG1 Kappa
Citations Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake. Cmejla R, et al. Biochem Biophys Res Commun, 2010 Apr 30. PMID 20188707.Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. Choi SH, et al. J Biol Chem, 2008 Apr 18. PMID 18263588.Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Lefort K, et al. Genes Dev, 2007 Mar 1. PMID 17344417.The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.A novel iron responsive element in the 3'UTR of human MRCKalpha. Cmejla R, et al. Biochem Biophys Res Commun, 2006 Mar 3. PMID 16412980.
NCBI NP_003598.2,NP_055641.3
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Similar products KIAA0451, CDC42-binding protein kinase alpha, Serine/threonine-protein kinase MRCK alpha, MRCK alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, Myotonic dystrophy protein kinase-like alpha, CDC42BPA {ECO:0000312|EMBL:CAH713361}
Lieferbar
Manufacturer - Targets
CDC42BPA (NP_003598, 551 a.a. ~ 650 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.
Clonality
Monoclonal
Gene Name
CDC42BPA {ECO:0000312|EMBL:CAH71336.1}
Subtitle
Mouse monoclonal antibody raised against a partial recombinant CDC42BPA.
Reactivity
H
Antigen Source
Human: ~~ Positive
Formulation
Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution
WB: 1:500~1000
E
Org Accession
NP_003598
Gene Description
CDC42 binding protein kinase alpha (DMPK-like)
Gene Summary
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq
Antigen Type
Recombinant Protein
Manufacturer - Alias
Serine/threonine-protein kinase MRCK alpha, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha, CDC42BPA {ECO:0000312|EMBL:CAH713361}, KIAA0451
Manufacturer - Similar
Serine/threonine-protein kinase MRCK alpha, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha, CDC42BPA {ECO:0000312|EMBL:CAH713361}, KIAA0451

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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