ELA2 Antibody (monoclonal) (M07)

P08246

E

Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes. Newburger PE, et al. Pediatr Blood Cancer, 2010 Aug. PMID 20582973.Effect of urinary trypsin inhibitor on preterm labor with high granulocyte elastase concentration in cervical secretions. Hayashi M, et al. J Nippon Med Sch, 2010 Apr. PMID 20453419.Structures of human proteinase 3 and neutrophil elastase--so similar yet so different. Hajjar E, et al. FEBS J, 2010 May. PMID 20423453.Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection. Niino T, et al. Thorac Cardiovasc Surg, 2010 Apr. PMID 20376727.Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass. Fujii M, et al. Interact Cardiovasc Thorac Surg, 2010 Jun. PMID 20354035.

1991

Mouse monoclonal antibody raised against a partial recombinant ELA2.

Detection limit for recombinant GST tagged ELA2 is approximately 0.3ng/ml as a capture antibody.

NM_001972

ELA2 (NP_001963, 168 a.a. ~ 267 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 1A11

0.25mg/ml

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein' s release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq