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FOXO3A Antibody (monoclonal) (M13)

FOXO3A Antibody (monoclonal) (M13)

ArtNr	ABC-AT2102a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	IF, IHC, ELISA
Clon	100000000000
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	FOXO3, FOXO3A, FKHRL1, Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1
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Primary Accession	O43524
Antigen Type	Recombinant Protein
Application	IHC, IF, E
Bio Background	This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
Bio References	An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma. Mikse OR, et al. Cancer Res, 2010 Aug 1. PMID 20631076.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Foxo3a regulates apoptosis by negatively targeting miR-21. Wang K, et al. J Biol Chem, 2010 May 28. PMID 20371612.
Clonality	Monoclonal
Gene ID	2309
Gene Name	FOXO3 (HGNC:3821)
Subtitle	Mouse monoclonal antibody raised against a partial recombinant FOXO3A.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to FOXO3 on HeLa cell . [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Immunoperoxidase of monoclonal antibody to FOXO3A on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml]
Type image 2	IHC
Legend image 3	Detection limit for recombinant GST tagged FOXO3A is approximately 0.03ng/ml as a capture antibody.
Type image 3	E
Other Accession	BC021224
Isotype	IgG1 Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	FOXO3A (AAH21224, 361 a.a. ~ 460 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001446.1; NP_963853.1
	Clone: 100000000000
Org Accession	AAH21224
Concentration	1 mg/ml
Gene Description	forkhead box O3
Gene Summary	This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq

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