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HOOK1 Antibody (monoclonal) (M02)

HOOK1 Antibody (monoclonal) (M02)

ArtNr	ABC-AT2400a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IHC, ELISA
Clon	1D11
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	HOOK1, Protein Hook homolog 1, h-hook1, hHK1
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Primary Accession	Q9UJC3
Antigen Type	Recombinant Protein
Application	WB, IHC, E
Bio Background	This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.
Bio References	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Xu L, et al. Mol Biol Cell, 2008 Dec. PMID 18799622.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Beausoleil SA, et al. Nat Biotechnol, 2006 Oct. PMID 16964243.The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
Clonality	Monoclonal
Gene ID	51361
Gene Name	HOOK1 (HGNC:19884)
Subtitle	Mouse monoclonal antibody raised against a partial recombinant HOOK1.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.41 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	Immunoperoxidase of monoclonal antibody to HOOK1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
Type image 2	IHC
Legend image 3	Detection limit for recombinant GST tagged HOOK1 is 0.3 ng/ml as a capture antibody.
Type image 3	E
Other Accession	NM_015888
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	HOOK1 (NP_056972, 632 a.a. ~ 728 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_056972.1
	Clone: 1D11
Org Accession	NP_056972
Gene Description	hook homolog 1 (Drosophila)
Gene Summary	This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq

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Menge: 100 ug

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