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ING3 Antibody (monoclonal) (M02)

ING3 Antibody (monoclonal) (M02)

ArtNr	ABC-AT2534a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF, ELISA
Clon	2C4
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG2b Kappa
Citations	The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system. Chen G, et al. Oncogene, 2010 Mar 11. PMID 19935701.High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Maestrini E, et al. Mol Psychiatry, 2010 Sep. PMID 19401682.Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer. Gunduz M, et al. Cancer Sci, 2008 Mar. PMID 18081876.Prognostic significance of nuclear ING3 expression in human cutaneous melanoma. Wang Y, et al. Clin Cancer Res, 2007 Jul 15. PMID 17634537.ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974.
NCBI	NP_061944.2,NP_938008.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Inhibitor of growth protein 3,p47ING3,ING3
Similar products	ING3, p47ING3, Inhibitor of growth protein 3
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Manufacturer - Targets	ING3 (NP_938008, 1 a.a. ~ 92 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Clonality	Monoclonal
Gene Name	ING3
Subtitle	Mouse monoclonal antibody raised against a partial recombinant ING3.
Reactivity	H, Rat
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	IF WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	NP_938008
Gene Description	inhibitor of growth family, member 3
Gene Summary	The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq
Antigen Type	Recombinant Protein

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Menge: 100 ug

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