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MAP2K6 Antibody (monoclonal) (M02)

MAP2K6 Antibody (monoclonal) (M02)

ArtNr	ABC-AT2773a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Cell Biology Cell Status Western Blot ELISA Immunofluorescence Senescence Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF, ELISA
Clon	2F2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation. Sturchler E, et al. Biochemistry, 2010 May 18. PMID 20364819.Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin. Huang HM, et al. J Cell Physiol, 2010 Jun. PMID 20162623.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Dumka D, et al. Leuk Lymphoma, 2009 Dec. PMID 19672773.
NCBI	NP_002749.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Dual specificity mitogen-activated protein kinase kinase 6,MAP kinase kinase 6,MAPKK 6,MAPK/ERK kinase 6,MEK 6,Stress-activated protein kinase kinase 3,SAPK kinase 3,SAPKK-3,SAPKK3,MAP2K6,MEK6,MKK6,PRKMK6,SKK3
Similar products	MAP2K6, MKK6, Dual specificity mitogen-activated protein kinase kinase 6, MAPK/ERK kinase 6, SAPKK3, MEK6, PRKMK6, SKK3, MAP kinase kinase 6, MAPKK 6, MEK 6, Stress-activated protein kinase kinase 3, SAPK kinase 3, SAPKK-3
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Manufacturer - Targets	MAP2K6 (AAH12009, 231 a.a. ~ 334 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
Clonality	Monoclonal
Gene Name	MAP2K6
Subtitle	Mouse monoclonal antibody raised against a partial recombinant MAP2K6.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	1 mg/ml
Dilution	IF WB: 1:500~1000 E
Org Accession	AAH12009
Gene Description	mitogen-activated protein kinase kinase 6
Gene Summary	This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq
Antigen Type	Recombinant Protein

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Menge: 100 ug

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