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MCM2 Antibody (monoclonal) (M01)

MCM2 Antibody (monoclonal) (M01)

ArtNr	ABC-AT2818a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Neural Lineage Markers Antibodies Immunoprecipitation Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF, IP, ELISA
Clon	6A8
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Immunohistochemical patterns of ProEx C in vulvar squamous lesions: detection of overexpression of MCM2 and TOP2A. Chen H, et al. Am J Surg Pathol, 2010 Sep. PMID 20697251.Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. Qian Z, et al. PLoS Pathog, 2010 Mar 19. PMID 20333247.Determination of cell proliferation using Mcm2 antigen and evaluation of apoptosis and TGF-beta1 expression in GH-secreting or clinically nonfunctioning pituitary adenomas. Dallago CM, et al. Endocr Pathol, 2010 Mar. PMID 20174894.
NCBI	NP_004517.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	DNA replication licensing factor MCM2,Minichromosome maintenance protein 2 homolog,Nuclear protein BM28,MCM2,BM28,CCNL1,CDCL1,KIAA0030
Similar products	MCM2, CCNL1, DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, BM28, CDCL1, KIAA0030
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Manufacturer - Targets	MCM2 (AAH07670, 805 a.a. ~ 904 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Clonality	Monoclonal
Gene Name	MCM2
Subtitle	Mouse monoclonal antibody raised against a partial recombinant MCM2.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	1 mg/ml
Dilution	IF IP WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000
Org Accession	AAH07670
Gene Description	minichromosome maintenance complex component 2
Gene Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. [provided by RefSeq
Antigen Type	Recombinant Protein

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