MEF2A Antibody (monoclonal) (M08)

Recombinant Protein

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.

Monoclonal

MEF2A

H

IF

WB

MEF2A monoclonal antibody (M08), clone 1F8. Western Blot analysis of MEF2A expression in HepG2 ( (Cat # AT2834a )

1:500~1000

WB

Detection limit for recombinant GST tagged MEF2A is approximately 0.1ng/ml as a capture antibody.

BC013437

Human: ~~ Positive

NP_001124398.1; NP_001124399.1; NP_001124400.1; NP_001165365.1; NP_005578.2

AAH13437

The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes ' agamous' and ' deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM