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MYCN Antibody (monoclonal) (M01)

MYCN Antibody (monoclonal) (M01)

ArtNr	ABC-AT2948a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Sarcoma Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ELISA
Clon	3H4
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Analysis of the REL, BCL11A, and MYCN proto-oncogenes belonging to the 2p amplicon in chronic lymphocytic leukemia. Deambrogi C, et al. Am J Hematol, 2010 Jul. PMID 20575024.Pleiotropic role for MYCN in medulloblastoma. Swartling FJ, et al. Genes Dev, 2010 May 15. PMID 20478998.Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma. Muth D, et al. Cancer Res, 2010 May 1. PMID 20424123.MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2. Foley NH, et al. Mol Cancer, 2010 Apr 21. PMID 20409325.Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor. Williams RD, et al. Clin Cancer Res, 2010 Apr 1. PMID 20332316.
NCBI	NP_005369.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	N-myc proto-oncogene protein,Class E basic helix-loop-helix protein 37,bHLHe37,MYCN,BHLHE37,NMYC
Similar products	MYCN, NMYC, bHLHe37, N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, BHLHE37
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Manufacturer - Targets	MYCN (NP_005369, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
Clonality	Monoclonal
Gene Name	MYCN
Subtitle	Mouse monoclonal antibody raised against a partial recombinant MYCN.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	NP_005369
Gene Description	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Gene Summary	This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq
Antigen Type	Recombinant Protein

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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