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NFYC Antibody (monoclonal) (M01)

NFYC Antibody (monoclonal) (M01)

ArtNr	ABC-AT3043a
Hersteller	Abcepta
Menge	50 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, IHC, ELISA
Clon	1D3
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	NFYC, NF-YC, Nuclear transcription factor Y subunit gamma, CAAT box DNA-binding protein subunit C, Nuclear transcription factor Y subunit C, Transactivator HSM-1/2
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Primary Accession	Q13952
Antigen Type	Recombinant Protein
Application	WB, IHC, IF, E
Bio Background	This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
Bio References	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. Ichikawa S, et al. J Bone Miner Res, 2010 Aug. PMID 20200978.NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. Murai-Takeda A, et al. J Biol Chem, 2010 Mar 12. PMID 20054001.NF-YC complexity is generated by dual promoters and alternative splicing. Ceribelli M, et al. J Biol Chem, 2009 Dec 4. PMID 19690168.Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers. Yamanaka K, et al. Genomics, 2009 Oct. PMID 19559782.Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Horikawa Y, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047128.
Clonality	Monoclonal
Gene ID	4802
Gene Name	NFYC
Subtitle	Mouse monoclonal antibody raised against a partial recombinant NFYC.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to NFYC on HeLa cell . [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Western Blot analysis of NFYC expression in transfected 293T cell line by NFYC monoclonal antibody (M01), clone 1D3. Lane 1: NFYC transfected lysate(37.2 KDa). Lane 2: Non-transfected lysate.
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Western blot analysis of NFYC over-expressed 293 cell line, cotransfected with NFYC Validated Chimera RNAi ( (Cat # AT3043a )
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Immunoperoxidase of monoclonal antibody to NFYC on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]
Type image 5	IHC
Legend image 6	Detection limit for recombinant GST tagged NFYC is 3 ng/ml as a capture antibody.
Type image 6	E
Other Accession	BC005003
Isotype	IgG3 Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	NFYC (AAH05003, 14 a.a. ~ 113 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001136059.1; NP_001136060.1; NP_001136061.1; NP_001136062.1; NP_055038.2
	Clone: 1D3
Org Accession	AAH05003
Gene Description	nuclear transcription factor Y, gamma
Gene Summary	This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

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