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OTUB1 Antibody (monoclonal) (M09)

OTUB1 Antibody (monoclonal) (M09)

ArtNr	ABC-AT3158a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Targets for Rodent Neurosciences Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ELISA
Clon	1C12
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	1.Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.Edelmann MJ, Kramer HB, Altun M, Kessler BM.FEBS J. 2010 Jun;277(11):2515-30.
NCBI	NP_060140.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Ubiquitin thioesterase OTUB1,Deubiquitinating enzyme OTUB1,OTU domain-containing ubiquitin aldehyde-binding protein 1,Otubain-1,hOTU1,Ubiquitin-specific-processing protease OTUB1,OTUB1,OTB1,OTU1
Similar products	OTUB1, OTU1, OTB1, Deubiquitinating enzyme OTUB1, hOTU1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin thioesterase OTUB1, Ubiquitin-specific-processing protease OTUB1
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Manufacturer - Targets	OTUB1 (AAH07519, 1 a.a. ~ 271 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.
Clonality	Monoclonal
Gene Name	OTUB1
Subtitle	Mouse monoclonal antibody raised against a full-length recombinant OTUB1.
Reactivity	H
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	0.5 mg/ml
Dilution	WB: 1:500~1000 E
Org Accession	AAH07519
Gene Description	OTU domain, ubiquitin aldehyde binding 1
Gene Summary	The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Antigen Type	Recombinant Protein

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ABC-AT3158a-datasheet.pdf

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Menge: 100 ug

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