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PAK1 Antibody (monoclonal) (M02)

PAK1 Antibody (monoclonal) (M02)

ArtNr	ABC-AT3173a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies By Cell Type Carcinoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF, IP, IHC, ELISA
Clon	4D1
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	1.Fragile X Related Protein 1 Clusters with Ribosomes and Messenger RNAs at a Subset of Dendritic Spines in the Mouse Hippocampus.Cook D, Del Rayo Sanchez-Carbente M, Lachance C, Radzioch D, Tremblay S, Khandjian EW, Desgroseillers L, Murai KK.PLoS One. 2011;6(10):e26120. Epub 2011 Oct 11.
NCBI	NP_001122092.1,NP_002567.3
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Serine/threonine-protein kinase PAK 1,Alpha-PAK,p21-activated kinase 1,PAK-1,p65-PAK,PAK1
Similar products	PAK-1, PAK1, Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, p65-PAK
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Manufacturer - Targets	PAK1 (NP_002567, 191 a.a. ~ 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Monoclonal
Gene Name	PAK1 {ECO:0000303\|PubMed:8805275, ECO:0000312\|HGNC:HGNC:8590}
Subtitle	Mouse monoclonal antibody raised against a partial recombinant PAK1.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	0.5 mg/ml
Dilution	IF IP WB: 1:500~1000 WB: 1:500~1000 IHC
Org Accession	NP_002567
Gene Description	p21 protein (Cdc42/Rac)-activated kinase 1
Gene Summary	PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Antigen Type	Recombinant Protein

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Menge: 100 ug

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