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PPIE Antibody (monoclonal) (M02)

PPIE Antibody (monoclonal) (M02)

ArtNr	ABC-AT3401a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, ELISA
Clon	2F5
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PPIE, CYP33, Peptidyl-prolyl cis-trans isomerase E, Cyclophilin E, Cyclophilin-33, Rotamase E, PPIase E
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Primary Accession	Q9UNP9
Antigen Type	Recombinant Protein
Application	WB, IF, E
Bio Background	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified.
Bio References	The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression . Park S, et al. Biochemistry, 2010 Aug 10. PMID 20677832.Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Wang Z, et al. Cell, 2010 Jun 25. PMID 20541251.Use of genome-wide expression data to mine the Gray Zone of GWA studies leads to novel candidate obesity genes. Naukkarinen J, et al. PLoS Genet, 2010 Jun 3. PMID 20532202.Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. Hom RA, et al. J Mol Biol, 2010 Jul 9. PMID 20460131.Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Chen J, et al. Cancer Res, 2008 Aug 1. PMID 18676843.
Clonality	Monoclonal
Gene ID	10450
Gene Name	PPIE
Subtitle	Mouse monoclonal antibody raised against a partial recombinant PPIE.
Reactivity	H, M, Rat
Legend image 1	Immunofluorescence of monoclonal antibody to PPIE on HeLa cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	PPIE monoclonal antibody (M02), clone 2F5. Western Blot analysis of PPIE expression in PC-12((Cat # AT3401a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	PPIE monoclonal antibody (M02), clone 2F5 Western Blot analysis of PPIE expression in Hela S3 NE ( (Cat # AT3401a )
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	PPIE monoclonal antibody (M02), clone 2F5. Western Blot analysis of PPIE expression in Raw 264.7((Cat # AT3401a )
Type image 5	WB
Dilution image 5	1:500~1000
Legend image 6	PPIE monoclonal antibody (M02), clone 2F5. Western Blot analysis of PPIE expression in NIH/3T3((Cat # AT3401a )
Type image 6	WB
Dilution image 6	1:500~1000
Legend image 7	Western Blot analysis of PPIE expression in transfected 293T cell line by PPIE monoclonal antibody (M02), clone 2F5. Lane 1: PPIE transfected lysate(33.4 KDa). Lane 2: Non-transfected lysate.
Type image 7	WB
Dilution image 7	1:500~1000
Other Accession	NM_006112
Isotype	IgG2a Kappa
Target/Specificity	PPIE (NP_006103, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001181936.1; NP_006103.1; NP_982281.1
	Clone: 2F5
Legend image 8	Detection limit for recombinant GST tagged PPIE is approximately 0.1ng/ml as a capture antibody.
Org Accession	NP_006103
Concentration	0.5 mg/ml
Gene Description	peptidylprolyl isomerase E (cyclophilin E)
Gene Summary	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities and also exhibit RNA-binding activity. Three alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq

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Menge: 100 ug

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