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RAP1A Antibody (monoclonal) (M01)

RAP1A Antibody (monoclonal) (M01)

ArtNr	ABC-AT3562a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Cell Biology Cytoskeleton Western Blot ELISA Primary Antibodies Immunostaining small GTPases Ras Subfamily Rap Subfamily
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ELISA
Clon	30
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	1.Overexpression of Rap-1A Indicates a Poor Prognosis for Oral Cavity Squamous Cell Carcinoma and Promotes Tumor Cell Invasion via Aurora-A Modulation.Chen CH, Chuang HC, Huang CC, Fang FM, Huang HY, Tasi HT, Su LJ, Shiu LY, Leu S, Chien CY.Am J Pathol. 2012 Dec 3. pii: S0002-9440(12)00817-6. doi: 10.1016/j.ajpath.2012.10.023. [Epub ahead of print]
NCBI	NP_001010935.1,NP_002875.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Ras-related protein Rap-1A,C21KG,G-22K,GTP-binding protein smg p21A,Ras-related protein Krev-1,RAP1A,KREV1
Similar products	RAP1A, G-22K, KREV1, Ras-related protein Rap-1A, C21KG, GTP-binding protein smg p21A, Ras-related protein Krev-1
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Manufacturer - Targets	RAP1A (AAH14086.1, 1 a.a. ~ 184 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
Clonality	Monoclonal
Gene Name	RAP1A
Subtitle	Mouse monoclonal antibody raised against a full length recombinant RAP1A.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 E
Org Accession	AAH14086.1
Gene Description	RAP1A, member of RAS oncogene family
Gene Summary	The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Antigen Type	Recombinant Protein

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100 ug

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