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RNF111 Antibody (monoclonal) (M05)

RNF111 Antibody (monoclonal) (M05)

ArtNr	ABC-AT3657a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Neural Signaling Protein Aggregation, Clearance & Misfolding Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Bladder Cancer Immunostaining
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF, ELISA
Clon	1C4
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	1.RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.Poulsen SL, Hansen RK, Wagner SA, van Cuijk L, van Belle GJ, Streicher W, Wikstrom M, Choudhary C, Houtsmuller AB, Marteijn JA, Bekker-Jensen S, Mailand NJ Cell Biol. 2013 Jun 10;201(6):797-807. doi: 10.1083/jcb.201212075.2.Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation.Erker Y, Neyret-Kahn H, Seeler JS, Dejean A, Atfi A, Levy LMol Cell Biol. 2013 Jun;33(11):2163-77. doi: 10.1128/MCB.01019-12. Epub 2013 Mar 25.3.RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination.Ma T, Chen Y, Zhang F, Yang CY, Wang S, Yu XMol Cell. 2013 Mar 7;49(5):897-907. doi: 10.1016/j.molcel.2013.01.006. Epub 2013 Feb 7.4.RB1CC1 positively regulates transforming growth factor-{beta} signaling through the modulation of Arkadia E3 ubiquitin ligase activity.Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K.J Biol Chem. 2011 Jul 27. [Epub ahead of print]5.Efficient TGF-beta/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression.Javelaud D, van Kempen L, Alexaki VI, Le Scolan E, Luo K, Mauviel A.Mol Cancer. 2011 Jan 6;10(1):2.6.Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.Nagano Y, Koinuma D, Miyazawa K, Miyazono K.J Biochem. 2010 Apr;147(4):545-54. Epub 2009 Dec 2.7.Overexpression of snon/skil, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis.Nanjundan M, Cheng KW, Zhang F, Lahad J, Kuo WL, Schmandt R, Smith-McCune K, Fishman D, Gray JW, Mills GB.Mol Oncol. 2008 Aug;2(2):164-81. Epub 2008 May 10.8.Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS.Mol Cell Biol. 2007 Sep;27(17):6068-83. Epub 2007 Jun 25.
NCBI	NP_001257457.1,NP_001257458.1,NP_001257459.1,NP_060080.6
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	E3 ubiquitin-protein ligase Arkadia,632-,RING finger protein 111,RNF111
Similar products	RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111, 632-
Lieferbar
Manufacturer - Targets	RNF111 (NP_060080, 1 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.
Clonality	Monoclonal
Gene Name	RNF111
Subtitle	Mouse monoclonal antibody raised against a partial recombinant RNF111.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	IF WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	NP_060080
Gene Description	ring finger protein 111
Gene Summary	The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development. [provided by RefSeq
Antigen Type	Recombinant Protein

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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ABC-AT3657a-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 01.01.2026

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