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SLC1A2 Antibody (monoclonal) (M07)

SLC1A2 Antibody (monoclonal) (M07)

ArtNr	ABC-AT3905a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Neural Signaling Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ELISA
Clon	1D8
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. Kantoj?rvi K, et al. Psychiatr Genet, 2010 Jun. PMID 20410850.Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. Saus E, et al. J Psychiatr Res, 2010 Apr 14. PMID 20398908.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease. Tian G, et al. J Neurochem, 2010 May. PMID 20193040.Comparative structural and functional analysis of the GLT-1/EAAT-2 promoter from man and rat. Allritz C, et al. J Neurosci Res, 2010 May 1. PMID 19998491.
NCBI	NP_001182657.1,NP_001239581.1,NP_004162.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Excitatory amino acid transporter 2,Glutamate/aspartate transporter II,Sodium-dependent glutamate/aspartate transporter 2,Solute carrier family 1 member 2,SLC1A2,EAAT2,GLT1
Similar products	EAAT2, SLC1A2, GLT1, Excitatory amino acid transporter 2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2
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Manufacturer - Targets	SLC1A2 (NP_004162, 160 a.a. ~ 239 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Clonality	Monoclonal
Gene Name	SLC1A2
Subtitle	Mouse monoclonal antibody raised against a partial recombinant SLC1A2.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	1mg/ml
Dilution	WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	NP_004162
Gene Description	solute carrier family 1 (glial high affinity glutamate transporter), member 2
Gene Summary	This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq
Antigen Type	Recombinant Protein

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ABC-AT3905a-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 01.01.2026

Express-Lieferung: 23 Tage sparen

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