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UCP1 Antibody (monoclonal) (M01)

UCP1 Antibody (monoclonal) (M01)

ArtNr	ABC-AT4458a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Obesity Western Blot ELISA Primary Antibodies Immunostaining Other Lipid\Cholesterol Metabolism Modulators
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ELISA
Clon	400000
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	The Effects of Uncoupling Protein 1 and beta3-Adrenergic Receptor Gene Polymorphisms on Weight Loss and Lipid Profiles in Obese Women. Kim JY, et al. Int J Vitam Nutr Res, 2010 Mar. PMID 20803423.Population Genetic Analysis of the Uncoupling Proteins Supports a Role for UCP3 in Human Cold Resistance. Hancock AM, et al. Mol Biol Evol, 2010 Aug 28. PMID 20802238.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Large copy number variations are enriched in cases with moderate to extreme obesity. Wang K, et al. Diabetes, 2010 Jul 9. PMID 20622171.Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
NCBI	NP_068605.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Mitochondrial brown fat uncoupling protein 1,UCP 1,Solute carrier family 25 member 7,Thermogenin,UCP1,SLC25A7,UCP
Similar products	UCP1, SLC25A7, UCP, Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin
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Manufacturer - Targets	UCP1 (NP_068605, 232 a.a. ~ 267 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
Clonality	Monoclonal
Gene Name	UCP1
Subtitle	Mouse monoclonal antibody raised against a partial recombinant UCP1.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	0.5mg/ml
Dilution	WB: 1:500~1000 E
Org Accession	NP_068605
Gene Description	uncoupling protein 1 (mitochondrial, proton carrier)
Gene Summary	Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq
Antigen Type	Recombinant Protein

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Menge: 100 ug

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