ERBB2 Antibody

ArtNr	ABC-AW5248-U100
Hersteller	Abcepta
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Western Blot Primary Antibodies By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer
Typ	Antibody Primary
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b Kappa
Citations	Yamamoto T.,et al.Nature 319:230-234(1986). Coussens L.,et al.Science 230:1132-1139(1985). Wakamatsu A.,et al.Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Tal M.,et al.Mol. Cell. Biol. 7:2597-2601(1987).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Receptor tyrosine-protein kinase erbB-2,Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2,CD340,ERBB2,HER2,MLN19,NEU,NGL
Similar products	ERBB2, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, Tyrosine kinase-type cell surface receptor HER2, MLN 19, HER2, NEU, NGL, MLN19, Metastatic lymph node gene 19 protein, CD340
Lieferbar
Manufacturer - Category	Primary Antibodies; Anti-Kinome Antibodies
Manufacturer - Targets	This ERBB2 antibody is generated from a mouse immunized with a recombinant protein.
Bio Background	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Clonality	Monoclonal
Gene Name	ERBB2
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Calculated Molecular Weight	137910
Antigen Source	HUMAN
Dilution	WB: 1:1000
Antigen Type	Recombinant Protein

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