Stat3 Monoclonal Antibody [Knockout Validated]

Crown Antibodies; Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Developmental Biology; Microbiology; Signal Transduction; Knockout Antibodies; Viral process; Host-virus interaction; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Interleukin signaling; JAK-STAT signaling; Jak-STAT signaling KEGG

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

STAT3 {ECO:0000303|PubMed:9630560, ECO:0000312|HGNC:HGNC:11364}

H

88068

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Recombinant Protein