Phospho BCL-2 [Thr56]

Rabbit anti-Threonine 56 phosphorylated Bcl-2 polyclonal antibody

A synthetic peptide (SQPGHTpPHPASR) derived from human Bcl-2, conjugated with KLH for immunization

Protein G affinity purified

Bcl-2 is a 25kD inner mitochondrial membrane protein with anti-apoptotic function. It is believed that Bcl-2 suppresses apoptosis by inhibiting mitochondrial cytochrome C release, blocking caspase cascade and regulating mitochondrial calcium homeostasis. Bcl-2 is identified from the study of B-cell lymphoma. About 90% of follicular lymphoma is caused by Bcl-2 over-expression resulted from the translocation of Bcl-2 gene from chromosome 18 to the immunoglobulin heavy chain enhancer on chromosome 14. Bcl-2 is also involved with other malignancies such as melanoma, breast cancer, prostate cancer and lung cancer. Bcl-2 Thr56 phosphorylation by p38 MAPK results in cytochrome C release. Mutation near Thr56 aborted Bcl-2 anti-apoptotic function.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Life science research, apoptotic signalling pathway