Phospho C-kit [Tyr719]

Rabbit anti-Tyrosine 719 phosphorylated c-kit polyclonal antibody

Protein G affinity purified

c-kit, also known as CD117, is a receptor tyrosine kinase expressed at the surface of mast cells and certain types of stem cells. c-kit is activated and autophosphorylated upon binding with stem cell factor. Activated c-kit phosphorylates downstream SH2-domain-containing signalling molecules such as PLCgamma, the p85 subunit of PI3 kinase, SHP2, and CrkL. The binding is impaired when c-kit is mutated at tyrosine719. c-kit with phosphorylated tyrosine 719 binds to the p85 subunit of PI3 kinase in vitro and in vivo. C-kit is encoded by KIT gene and the gene is frequently over-expressed in gastrointestinal stromal tumor, myelogenous leukemia, and testicular germ cell tumor. Mutational loci of the gene are implicated with responsiveness to cancer drug imatinib.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Life science research, cell signalling, cancer research