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mAb anti-Human TNF-a

Hersteller Anogen
Kategorie
Typ Antibody Monoclonal
Specific against Human
Clon B1E4
Isotype IgG1 kappa
Applikationen WB, ELISA, Blocking, IS
Menge 0.1mg
Host Mouse
ArtNr ANOG-MO-C40003E-0.1mg
Targets TNF
eClass 6.1 32160702
eClass 9.0 42030590
Lieferbar
Description
Mouse monoclonal antibody to human Tumor Necrosis Factor alpha (TNF-alpha)
Target Protein
Human TNF-alpha
Immunogen
Purified recombinant human TNF-alpha
Specificity
This antibody recognizes recombinant human TNF-alpha in ELISA and Western Blotting.
Purification
Protein G affinity purified
Myeloma
Sp2/0-Ag14
Light chain
Kappa
Background
Tumor Necrosis Factor-alpha (TNF-alpha) is a multifunctional pro-inflammatory cytokine, mainly secreted by activated macrophages. TNF-alpha was named for its remarkable ability to cause hemorrhagic necrosis to tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. The pleiotropic attribute of TNF-alpha regulation is associated with its ability to trigger multiple signalling pathways simultaneously. It is well documented that TNF-alpha functions through its receptors, TNFR1 (p55) and TNFR2 (p75). TNF-alpha not only contributes to the immune response to bacterial, fungal, viral and parasitic invasions, but also functions in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. TNF-alpha hyper-expression in response to some bacterial components such as LPS can cause life threatening septic shock. Recombinant TNF-alpha, in combination with chemotherapy, has been applied for treatment of soft sarcomas, melanomas and other irresectable tumors. Anti-TNF-alpha therapy has been used for treatment of rheumatoid arthritis.
Formulation
Lyophilized from a solution in 0.01M PBS, pH 7.0
Reconstitution
Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Research Area
Cytokines and Growth Factors
Storage
Store at -20oC

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 0.1mg
Lieferbar: In stock
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Lieferung vsl. bis 13.05.2024 

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