Interferon Gamma (IFN-gamma)

Human IFN-gamma

This antibody recognizes both recombinant and native human IFN-gamma.

Human, other species not tested

IFN-gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL), effector T cells once antigen-specific immunity develops. IFN-gamma stimulates its own expression and up-regulates other genes to stimulate and modulate immunity mainly through the Jak-Stat signalling pathway. It promoters T helper 1 differentiation and cell associated immunity, and also suppresses T helper 2 differentiation and humoral immunity.
IFN-gamma is a potent macrophage activator. It binds to macrophage in conjugation with CD40, causing the macrophage to produce elevated amounts of MHC molecules. It also stimulates the production of antigen-processing associated transporters and enzymes.
IFN-gamma is critical for anti-tumour and anti-viral immunity.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Pro-inflammatory cytokine, anti-tumour and anti-viral immunity