mAb anti-Human IL-1beta

Mouse monoclonal antibody to human Interleukin-1 beta (IL-1beta)

Purified recombinant human IL-1beta

Protein G affinity purified

Sp2/0-Ag14

Interleukin 1beta (IL-1beta) shares the IL-1 receptor with other cytokines in IL-1 family. It is primarily produced by activated macrophage as a proprotein, which is cleaved by caspase I to become active. Like IL-1alpha, IL-1beta is an important mediator of innate immunity. IL-1beta stimulates lymphocyte proliferation and the production of TNF-alpha, IL-6 and IL-8. IL-1beta and TNF-alpha can synergically act at NFkB and mitogen kinases including JNKs and p38 MARKs, thus leading to the selective expression of genes for immunity and inflammation.

Double distillated water is recommended to reconstitute the antibody.

Store at -20oC