Granulocyte-Colony Stimulating Factor Receptor (G-CSFR)

Human G-CSFR

Reactive with G-CSFR and does not cross-react with MBP or BSA (bovine serum albumin)

Human, other species not tested

Granulocyte colony stimulating factor receptor (G-CSFR) exists on the cell surface of the hematopoietic progenitor cell in bone marrow, in mature hematopoietic cells and stromal cells. Binding with granulocyte colony stimulating factor (G-CSF) to the extracellular ligand-binding region of G-CSFR triggers G-CSFR to form homodimer. The conformational changes in G-CSFR activate the cytoplasmic portion of the receptor and trigger signal transduction through Jak Lyn, Stat and erk1/2. The pathway is important for hematopoiesis and was found to be implicated in congenital neutropenia, myelodysplastic syndrome and acute myeloid leukemia.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Cytokine receptor. Hematopoiesis