Human Transferrin

Human transferrin receptor

Reactive with human transferrin receptor

Human, others not tested.

Transferrin receptor, also known as CD71 or p90, is expressed at the surface of cells that utilize iron. The receptor binds transferrin and internalizes iron carried with it. Like many other proteins involved with iron metabolism, transferrin receptor is regulated by iron response element-binding proteins (IRE-BPs). Transferrin receptor is highly expressed in erythroid cells, placental tissue, and rapidly dividing cells. When iron concentration in the cells is low, IRE-BPs bind to the IREs on the mRNA of transferrin receptor to increase the transcription of the receptor.
Transferrin receptors in macrophage, T-cells and B lymphocyte are increased during activation.

Double distillated water is recommended to adjust the final concentration to 1.00mg/mL.

Iron metabolism